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PR Newswire
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Issue of equity to raise approximately GBP3 million

8 December 2009

                               Verona Pharma plc                               

                          ("Verona" or the "Company")                          

                                 (AIM: VRP.L)                                  

               Issue of equity to raise approximately £3 million               

The Board of Verona Pharma plc, the AIM quoted drug discovery company, is
pleased to announce that it proposes to raise approximately £3 million, before
expenses, at a price of 13 pence per share, via a placing arranged on the
Company's behalf by Evolution Securities Limited and a subscription
("Fundraising"). The net proceeds will be applied to develop further the
Company's lead drug, RPL554, as well as its two other drug development
projects: Cough and NAIPs, whilst the Company pursues licensing partnership
opportunities for RPL554.

The Fundraising is conditional, inter alia, upon the Company obtaining approval
from the Shareholders to grant the Board authority to allot the New Ordinary
Shares and to disapply statutory pre-emption rights which would otherwise apply
to the allotment of the New Ordinary Shares.

Highlights

  * The Company proposes to raise approximately £3 million, before expenses, by
    the issue of up to 23,265,684 New Ordinary Shares at 13 pence per Ordinary
    Share
   
  * The money raised will be used to further develop RPL554, as well as its two
    other drug development projects: Cough and NAIPs
   
  * The Company continues to actively pursue licensing partnership
    opportunities for the future development of RPL554, and is currently in
    discussions with potential partners
   
  * The Company has taken the opportunity to raise the funds to progress work
    on the Cough and NAIPs projects while it continues to seek the most
    appropriate licensing partnership
   
  * The funding will also assist the Company as it continues to search for
    additional intellectual property ("IP") that meets its tightly defined
    areas of expertise
   
  * The Company has a low cash burn rate due to the "semi-virtual" nature of
    its operations
   
  * The Company has a complementary portfolio of respiratory drugs, which
    includes RPL554 and two further projects: Cough and NAIPs
   
Commenting on the Fundraising, Prof. Michael Walker, Chief Executive Officer of
Verona said:

"We are delighted to announce the fundraising to raise approximately £3
million, before expenses, in order to progress RPL554 and further develop the
remaining projects in our portfolio. This is an extremely exciting period for
us as we continue to work towards the commercialisation of RPL554. We are in
discussions with potential licensing partners and look forward to updating the
market in due course.

"With new funding in place we can actively pursue new IP and continue to
advance our Cough and NAIPs projects alongside RPL554. We look forward to the
future with confidence."

Enquiries

For more information please contact:                                           
                                                                               
Professor Clive Page                    020 7863 3300                          
                                                                               
Chairman, Verona Pharma plc                                                    
                                                                               
Barry Saint / Tim Redfern / Esther Lee  020 7071 4300                          
                                                                               
Evolution Securities Limited                                                   
                                                                               
Suzanne Johnson-Walsh / Gemma O'Hara    020 7562 3350                          
                                                                               
Bishopsgate Communications                                                     

Current trading and prospects

While investigating licensing and partnering possibilities for RPL554, the
Company continues to advance its other two current drug discovery projects, the
Cough Project and the NAIPs Project. The Company continues to maintain a low
cash burn rate, due to the "semi-virtual" nature of its operations and its
sustained drive for efficient progress. At 31 October 2009, the Company had
cash and short-term deposits of £1.2million.

In addition, the Company plans to continue its search for additional drug
discovery projects that fit within the Company's tightly defined area of
expertise. The Directors believe that the current situation, where a number of
large international pharmaceutical companies have patents that are due to
expire, provides a significant commercial opportunity for companies like Verona
and its drug discovery projects.

Background to and reasons for the fundraising

On 11 September 2009, the Company announced the final results of its clinical
proof of concept trial for its lead drug compound RPL554. The study showed
clear clinical benefits in patients with asthma and allergic rhinitis and a
good safety profile. The Company is now actively seeking a licensing
partnership to fund the further development of RPL554, and is currently in
discussions with potential licensing partners.

The net proceeds of the Fundraising are intended to pay for ongoing clinical
development of RPL554 and to fund the working capital for the Group as it
continues to develop its drug portfolio, whilst the Company seeks a licensing
partner for RPL554. In addition, the funding will assist the Company as it
continues to seek additional IP within its tightly defined areas of expertise.

Details of the Fundraising

The Company proposes to raise a total of approximately £2.7 million (net of
expenses) by the issue of up to 22,457,223 Placing Shares at the Issue Price to
placees, of which 6,205,300 Placing Shares will be placed with investors who
may wish to fall within the Enterprise Investment Scheme ("EIS") within the
meaning of the relevant legislation.

The Company has applied for provisional advance assurance from HM Revenue &
Customs ("HMRC") that, subject to all relevant conditions being fulfilled, any
holding of Placing Shares issued to an investor wishing to fall within the EIS
will be regarded by HMRC as satisfying the requirements of the EIS.

The Directors intend to manage the Company so as to be in a position to
maintain this status (so far as reasonably practicable within the commercial
objectives of the Company and with regard to their duties and obligations as
Directors), although no assurance can be given in this regard.

The Company also proposes to raise a further £0.1 million (net of expenses)
through the subscription for a further 808,461 new Ordinary Shares by Trevor
Jones, a Director of the Company, and another individual, both at the Issue
Price and on substantially the same terms as the Placing ("the Subscription").

The Issue Price represents a discount of 10.34 per cent. to the closing middle
market price of 14.50 pence per Ordinary Share on 7 December 2009, being the
last practicable date prior to the announcement of the Fundraising. The New
Ordinary Shares will represent approximately 9.74 per cent. of the Enlarged
Share Capital.

The General Meeting to seek the Shareholders' approval for the Fundraising will
be held at 9.00 a.m. on 24 December 2009 at the offices of Sprecher Grier
Halberstam LLP at 5th Floor, One America Square, Crosswall, London EC3N 2SG. A
circular to Shareholders convening the General Meeting is being despatched
today.

Application will be made for 17,060,384 of the New Ordinary Shares to
be admitted to AIM. Trading in those New Ordinary Shares is expected to
commence on 29 December 2009. Upon receipt of the provisional advance assurance
from HMRC in relation to the remaining 6,205,300 of the New Ordinary Shares (or
following agreement of the relevant placees to invest without it being
obtained), the Company will make an application for some or all of such shares
(as the case may be) to be admitted to trading on AIM and trading in these
shares is expected to commence three business days later (provided that such
admission shall not occur before 29 December 2009).

The New Ordinary Shares will, when issued, rank pari passu in all respects with
the existing Ordinary Shares, including the right to receive dividends and
other distributions declared following date of allotment.

Substantial Shareholder's and Director's participation in the Fundraising

Williams de Broe is an existing substantial shareholder of the Company and has
agreed to subscribe for 7,435,300 Placing Shares. Professor Trevor Jones, a
Non-Executive Director of the Company, has also agreed to subscribe for 38,461
New Ordinary Shares pursuant to the Subscription at the Issue Price.

                               ISSUE STATISTICS                                

Issue Price                                                                 13p
                                                                               
Number of Ordinary Shares in issue as at the date of this           215,481,355
document                                                                       
                                                                               
Number of Placing Shares being placed on behalf of the               22,457,223
Company                                                                        
                                                                               
Number of Subscription Shares being issued in connection                808,461
with the Subscription                                                          
                                                                               
Estimated proceeds of the Placing receivable by the                £2.7 million
Company, net of expenses                                                       
                                                                               
Estimated proceeds of the Subscription receivable by the           £0.1 million
Company, net of expenses                                                       
                                                                               
Number of Ordinary Shares in issue following Admission(1)           238,747,039
                                                                               
New Ordinary Shares as a percentage of the Enlarged Share        9.74 per cent.
Capital(1)                                                                     

(1) Assumes no Ordinary Shares are issued between the date of this announcement
and Admission and that all of the New Ordinary Shares are admitted to trading
on AIM

                                  DEFINITIONS                                  

The following definitions apply throughout this announcement unless the context
otherwise requires:

"Admission"                 admission of the relevant New Ordinary Shares to   
                            trading on AIM becoming effective in accordance    
                            with Rule 6 of the AIM Rules                       
                                                                               
"AIM Rules"                 the rules governing the admission to and operation 
                            of AIM as published by the London Stock Exchange   
                            from time to time                                  
                                                                               
"Company" or "Verona"       Verona Pharma plc                                  
                                                                               
"Cough Project"             the Company's project to discover new potent,      
                            efficacious and patentable molecules for inhibiting
                            cough                                              
                                                                               
"Directors" or "Board"      the directors of the Company as at the date of this
                            announcement or any duly authorised committee      
                            thereof                                            
                                                                               
"EIS"                       Enterprise Investment Scheme                       
                                                                               
"EIS Shares"                the 6,250,300 placing shares to be issued to       
                            certain placees and the subject of HMRC's          
                            provisional advance assurance                      
                                                                               
"Enlarged Share Capital"    the Ordinary Shares in issue immediately following 
                            Admission assuming all of the New Ordinary Shares  
                            are admitted to trading on AIM                     
                                                                               
"Evolution Securities"      Evolution Securities Limited, the Company's        
                            nominated adviser and broker                       
                                                                               
"Fundraising"               collectively, the Placing and the Subscription     
                                                                               
"HMRC"                      HM Revenue & Customs                               
                                                                               
"GM" or "General Meeting"   the general meeting of the Company to be held at   
                            9.00 a.m. on 24 December 2009                      
                                                                               
"Group"                     the Company and its subsidiaries                   
                                                                               
"Issue Price"               13 pence per New Ordinary Share                    
                                                                               
"London Stock Exchange"     London Stock Exchange plc                          
                                                                               
"NAIPs Project"             the Company's project to discover novel            
                            anti-inflammatory polysaccharides                  
                                                                               
"New Ordinary Shares"       the 23,265,684 new Ordinary Shares to be issued in 
                            connection with the Fundraising                    
                                                                               
"Ordinary Shares"           ordinary shares of 0.1p each in the capital of the 
                            Company                                            
                                                                               
"Placing"                   the conditional placing by Evolution Securities of 
                            the Placing Shares pursuant to the Placing         
                            Agreement                                          
                                                                               
"Placing Agreement"         the conditional agreement dated 8 December 2009    
                            between the Company and Evolution Securities       
                            relating to the Placing                            
                                                                               
"Placing Shares"            the 22,457,223 new Ordinary Shares to be issued in 
                            connection with the Placing including the EIS      
                            Shares                                             
                                                                               
"Shareholders"              holders of Ordinary Shares                         
                                                                               
"Subscription"              the conditional subscription at the Issue Price for
                            the Subscription Shares by Professor Trevor Jones  
                            and another individual pursuant to subscription    
                            letters entered into between each of them and the  
                            Company, on substantially the same terms as the    
                            Placing                                            
                                                                               
"Subscription Shares"       the 808,461 new Ordinary Shares to be issued in    
                            connection with the Subscription                   

Disclaimer

Evolution Securities Limited, which is authorised and regulated by the
Financial Services Authority, is acting as nominated adviser and broker to the
Company in connection with the Placing. Its responsibilities as the Company's
nominated adviser and broker under the AIM Rules for Nominated Advisers are
owed solely to London Stock Exchange and are not owed to the Company or to any
director or to any person. Evolution Securities Limited will not be responsible
to anyone other than the Company for providing the protections afforded to
clients of Evolution Securities Limited or for advising any other person in
relation to the Placing and any other arrangements described in this
announcement. Evolution Securities Limited has not authorised the contents of,
or any part of, this announcement and no liability whatsoever is accepted by
Evolution Securities Limited for the accuracy of any information or opinions
contained in this announcement or for the omission of any information.

Notes To Editors

About Verona Pharma plc (www.veronapharma.com )

Verona Pharma plc (AIM : VRP.L) is an AIM-quoted life sciences company
dedicated to the research, discovery and development of new therapeutic drugs
for the treatment of respiratory diseases including allergic rhinitis (hay
fever), asthma and chronic obstructive pulmonary disease.


The Company currently has three drug projects under development - RPL554, Cough
and NAIPs - and continues to look for other possible drug development
opportunities in the respiratory and inflammatory diseases markets.

Globally, treatment of these diseases costs an estimated US$20 billion per
annum. Despite such diseases being among the most prevalent in the
industrialised world, many of the current treatments have unwanted side
effects, and/or limited effectiveness.

Verona was admitted to AIM in September 2006, and is run by two world experts
in pharmacology and drug discovery. Michael Walker, CEO of Verona, is Emeritus
Professor of Anesthesiology, Pharmacology and Therapeutics at the University of
British Columbia, and a founder of other biotech, and biotech related
companies. Chairman, Clive Page, is a Professor of Pharmacology at King's
College London, and an internationally recognised authority in lung diseases
and inflammation.

RPL554

Verona's lead drug compound, RPL554, is a novel long acting inhibitor of both
phosphodiesterase 3 and phosphodiesterase 4 enzymes, two enzymes known to be of
importance in the development and progression of immunological respiratory
diseases, particularly rhinitis (hay fever), asthma and possibly COPD. As a PDE
3 inhibitor, the drug is expected to result in bronchodilator actions, whilst
the PDE 4 component is expected to be anti-inflammatory.

RPL554 was selected from a class of compounds co-invented by Sir David Jack,
the former Director of Research at Glaxo who led the team that discovered many
of the commercially successful drugs in the respiratory market.

The competitive advantages of RPL554 include the following:

  * combining bronchodilator (PDE 3) and anti-inflammatory actions (PDE 4) in a
    single drug, something that is currently achieved with a combination long
    acting beta agonist ("LABA") plus a glucocorticosteroid in an inhaler;
   
  * does not use steroids or beta agonists, which have known side effects;
   
  * planned to be administered by inhalation, thereby reducing the unwanted
    gastrointestinal side effects of many orally administered drugs; and
   
  * expected to be long acting, thereby allowing once a day treatment which is
    likely to increase medication compliance.
   
During the first half of 2007, the synthetic pathway for the production of
scaleable quantities of the RPL554 compound was developed and a sufficient
quantity to complete planned preclinical and clinical studies was manufactured.
In May 2008, Verona completed toxicological studies of RPL554 according to Good
Laboratory Practices with LAB Research Inc. of Hungary, successfully
establishing that the compound is safe to give to man in clinical trials. In
February 2009, a Phase I/IIa clinical trial of RPL554 was commenced at the
Centre for Human Drug Research at Leiden in the Netherlands. In September 2009,
the Company announced that it had successfully completed the trial,
demonstrating that the drug had a good safety profile and had beneficial
effects in terms of bronchodilation and bronchoprotection in asthmatics and a
clear trend for a reduction in the numbers of inflammatory cells in the nasal
passages of allergic rhinitis patients although this did not reach statistical
significance. The Company is currently seeking licensing agreements or
partnerships for the further development and commercialisation of RPL554.

Cough

In November 2007, Verona announced that it had acquired significant know-how
for a potential anti-tussive drug. This potential drug treatment appears to act
to suppress the generation of the cough signals generated at the nerve endings
in the lungs that initiate and sustain coughing. The Company is currently
undergoing studies of a selected compound with the intention of commencing
preclinical safety and effectiveness evaluation studies in early 2010.

The programme will address the problem that while unexplained cough is one of
the most common medical complaints, there remains no truly effective treatment
for what can be a very debilitating condition. Most anti-cough treatments
currently available are either morphine-based, or derivatives of morphine, but
the limited efficacy and side effects of morphine, including its addictive
effects, limit its use.

NAIPs

Verona's longer term focus is to investigate and apply new synthetic and
analytical chemical techniques to the discovery and development of novel
polysaccharide drugs. Verona is focussed on drugs that have anti-inflammatory
effects that could prove useful in the treatment of various respiratory
diseases as well as other diseases in which inflammation occurs. The
polysaccharide, heparin, is a well known anti-coagulant that has been shown to
have anti-inflammatory effects in a range of diseases, but it is limited by its
anti-coagulant effect.

Verona has identified a natural source of novel anti-inflammatory
polysaccharide (NAIPs) without anti-coagulant actions in certain marine
organisms, such as starfish. The Company is working in collaboration with
Glycomar Limited of Scotland and Glycores 2000 S.r.l. of Italy to source and
screen various naturally occurring and synthesised novel polysaccharide
compounds as potential lead candidates for its NAIPs programme.  

UKMAT:12000878.3

                                       1                                       

                                       1                                       

UKMAT:12000878.3



END

VERONA PHARMA PLC

© 2009 PR Newswire
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