PD-1 and PD-L1 inhibitors clinical trial pipeline constitutes 180+ key companies continuously working towards developing 200+ PD-1 and PD-L1 inhibitors drugs, analyzes DelveInsight
LAS VEGAS, Nov. 14, 2022 /PRNewswire/ -- DelveInsight's 'PD-1 and PD-L1 Inhibitors Competitive Landscape - 2022' report provides comprehensive global coverage of available, marketed, and pipeline PD-1 and PD-L1 inhibitors drugs in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the PD-1 and PD-L1 inhibitors competitive domain.
Key Takeaways from the PD-1 and PD-L1 Inhibitors Pipeline Report
- Over 180+ PD-1 and PD-L1 inhibitors companies are evaluating 200+ PD-1 and PD-L1 inhibitors pipeline therapies in various stages of development, and their anticipated acceptance in the PD-1 and PD-L1 inhibitors market would significantly increase market revenue.
- Leading PD-1 and PD-L1 inhibitors companies such as Merck, Laekna Therapeutics, Genentech, Tracon Pharmaceuticals Inc., Celgene, MedImmune, Hangzhou Sumgen Biotech, Lepu Biopharma, Harbour BioMed, Curis, BeiGene, Apollomics, Agenus, Boehringer Ingelheim, Jounce Therapeutics, Seagen Inc., Ascletis Pharma Inc., Secarna Pharmaceuticals GmbH & Co. KG, Arbutus Biopharma, ABL bio, Macrogenics, AnaptysBio, Avacta, Regeneron Pharmaceuticals, Genor Biopharma Co. Ltd, Genmab, RemeGen, Alphamab, OxSonics therapeutics, Light Chain Bioscience, ImmuneOnco Biopharma, Alpine Immune Sciences, Shanghai Henlius Biotech, Inc., Ocean Biomedical, Akeso Biopharma, Lyvgen Biopharma, Prestige Biopharma, ONO PHARMACEUTICAL CO., LTD., Innovent Biologics, QLSF Biotherapeutics Inc., Servier, Zai Lab, EQRx, Bright Peak Therapeutics, Compass Therapeutics, Inc., Y-Biologics, Shattuck Labs, Beijing Biocytogen, Transcenta Holding, KLUS Pharma Inc., Synermore Biologics, F-Star Therapeutics Inc., Alphamab Oncology, Betta Pharmaceuticals Co., Ltd., Bolt Biotherapeutics, Medicenna Therapeutics, Celldex Therapeutics Inc., TCR² Therapeutics, Transcenta Holding, Merus, SystImmune Inc., TG Therapeutics, Elpiscience, Numab, Janux Therapeutics, Adagene, Molecular Templates, Inc., ImmuneOncia, and others are evaluating novel PD-1 and PD-L1 inhibitors drug candidates to improve the treatment landscape.
- Key PD-1 and PD-L1 inhibitors pipeline therapies in various stages of development include Envafolimab, Keytruda, FAZ053, TECENTRIQ, Durvalumab, SG 12473, LP 002, HBM 9027, CA 170, Tislelizumab, Geptanolimab, and others.
- In October 2022,ChemoCentryx, Inc. announced two upcoming poster presentations for CCX559, the Company's investigational, highly potent, orally administered PD-L1 checkpoint inhibitor, at the Society for Immunotherapy of Cancer (SITC) 37th Annual Meeting, which will be held November 8-12, 2022, in Boston, MA.
- In October 2022, Compugen Ltd., a clinical-stage cancer immunotherapy company and a pioneer in computational target discovery, announced that it will present new clinical data from its COM701/nivolumab with or without BMS-986207 combination studies in patients with platinum-resistant ovarian cancer, as well as data from the COM701 with or without nivolumab study in patients with metastatic NSCLC, as poster presentations at the European Society of Medical Oncology Immuno-Oncology (ESMO-IO) congress taking place between December 7-9, 2022, in Geneva, Switzerland.
- In October 2022, Imjudo (tremelimumab) from AstraZeneca was approved in the United States in combination with Imfinzi (durvalumab) for the treatment of adult patients with unresectable hepatocellular carcinoma (HCC), the most common type of liver cancer.
- In October 2022, GSK announced positive top-line results from the PERLA phase II trial, which met its primary endpoint of objective response rate (ORR) by Response Evaluation Criteria in Solid Tumors (RECIST) criteria as determined by blinded independent central review.
- In September 2022, Merck announced that KEYTRUDA, Merck's anti-PD-1 therapy, received four new approvals from Japan's Ministry of Health, Labor, and Welfare (MHLW).
- InJuly 2022, TRACON Pharmaceuticals, Inc. announced the enrollment of the 36^th patient in the ENVASARC pivotal trial at the 600 mg dose of envafolimab, which enables the initial independent data monitoring committee (IDMC) interim efficacy analysis to proceed. The interim analysis is expected to occur in the fourth quarter of this year.
- InJanuary 2022, Merck announced that the European Commission had approved KEYTRUDA as monotherapy for the adjuvant treatment of adults with renal cell carcinoma (RCC) at increased risk of recurrence following nephrectomy or following nephrectomy and resection of metastatic lesions.
Request a sample and discover the recent advances in the PD-1 and PD-L1 inhibitors market @PD-1 and PD-L1 Inhibitors Competitive Landscape Report
PD-1 and PD-L1 Inhibitors Overview
Cancer cells have programmed cell death protein 1 (PD-1) on their surfaces. Tumors use it to evade the immune system, so blocking it allows the body to attack and kill cancer. T cells constantly scan our bodies for abnormal cells and eliminate them before they can become cancerous. Finding ways to avoid or shut down the immune system is a critical step in tumor development. PD-1 proteins interact with two ligands, Programmed death-ligand 1 (PD-L1) and Programmed death-ligand 2 (PD-L2). The CD274 gene in humans encodes PD-L1.
Some of the FDA-approved PD-1 inhibitor drugs include pembrolizumab (Keytruda), nivolumab (Opdivo), and cemiplimab (Libtayo). These drugs effectively treat various cancers, and new cancer types are added as more research demonstrates their efficacy. PD-L1 inhibitor drugs include atezolizumab (Tecentriq), avelumab (Bavencio), and durvalumab (Imfinzi).
Find out more about PD-1 and PD-L1 inhibitors drugs @FDA-approved PD-1 Inhibitor Drugs
PD-1 and PD-L1 Inhibitors Pipeline Analysis: Drug Profile
Keytruda: Merck
Merck's Keytruda is a humanized monoclonal antibody that binds to the programmed cell death - 1 (PD-1) receptor and blocks its interaction with PD-L1 and PD-L2, releasing PD-1 pathway-mediated inhibition of the immune response, including anti-tumor immune response.
Keytruda has been approved for advanced melanoma, non-small cell lung cancer (NSCLC), head and neck squamous cell cancer, classical Hodgkin lymphoma, microsatellite-instability-high cancer, Gastric Cancer, Esophageal Cancer, Cervical Cancer, Hepatocellular Carcinoma, Merkel Cell Carcinoma, Renal Cell Carcinoma, Endometrial Carcinoma, and advanced urothelial bladder cancer.
FAZ053: Laekna Therapeutics
Laekna Therapeutics is developing FAZ053 (anti-PD-L1), an investigational immuno-oncology treatment for patients with advanced cancers. It is a monoclonal antibody that targets the protein programmed cell death-1 ligand 1. (PD-L1). FAZ053, an anti-PD-L1 monoclonal antibody, binds to PD-L1, preventing it from binding to and activating its receptor programmed death 1 (PD-1), potentially enhancing the T-cell-mediated anti-tumor immune response and reversing T-cell inactivation. Laekna intends to begin trials on combination therapies as soon as possible to address unmet cancer needs and bring innovative, effective treatments to more cancer patients in China.
A snapshot of the PD-1 and PD-L1 Inhibitors Pipeline Drugs mentioned in the report:
Drugs | Company | Phase | Indication |
Keytruda | Merck | Pre-registration | Adenocarcinoma |
Tislelizumab | BeiGene | Pre-registration | Gastric cancer |
Geptanolimab | Apollomics | Pre-registration | Peripheral T-cell lymphoma |
TECENTRIQ | Genentech | Phase II | Bladder cancer; Cervical cancer; Colorectal cancer; Fallopian tube cancer; Head and neck cancer; Mesothelioma; Oesophageal cancer; Ovarian cancer; Peritoneal cancer; Prostate cancer; Renal cell carcinoma |
Envafolimab | Tracon Pharmaceuticals Inc. | Phase III | Biliary cancer |
Durvalumab | Celgene/MedImmune | Phase III | Bladder cancer; Cervical cancer; Endometrial cancer; Fallopian tube cancer; Gastric cancer; Head and neck cancer; Liver cancer; Mesothelioma; Oesophageal cancer; Ovarian cancer; Peritoneal cancer; Renal cell carcinoma; Solid tumours |
CA 170 | Curis | Phase II/III | Non-small cell lung cancer |
FAZ053 | Laekna Therapeutics | Phase I/II | Solid tumors |
SG 12473 | Hangzhou Sumgen Biotech | Phase I | Cancer |
LP 002 | Linton Pharm | Preclinical | Chronic lymphocytic leukemia; Diffuse large B cell lymphoma; Non-Hodgkin's lymphoma |
Learn more about the emerging PD-1 and PD-L1 inhibitors pipeline therapies @PD-1 and PD-L1 Inhibitors Clinical Trials
Scope of the PD-1 and PD-L1 Inhibitors Competitive Landscape Report
- Coverage: Global
- Key PD-1 and PD-L1 Inhibitors Companies: Merck, Laekna Therapeutics, Genentech, Tracon Pharmaceuticals Inc., Celgene, MedImmune, Hangzhou Sumgen Biotech, Lepu Biopharma, Harbour BioMed, Curis, BeiGene, Apollomics, Agenus, Boehringer Ingelheim, Jounce Therapeutics, Seagen Inc., Ascletis Pharma Inc., Secarna Pharmaceuticals GmbH & Co. KG, Arbutus Biopharma, ABL bio, Macrogenics, AnaptysBio, Avacta, Regeneron Pharmaceuticals, Genor Biopharma Co. Ltd, Genmab, RemeGen, Alphamab, OxSonics therapeutics, Light Chain Bioscience, ImmuneOnco Biopharma, Alpine Immune Sciences, Shanghai Henlius Biotech, Inc., Ocean Biomedical, Akeso Biopharma, Lyvgen Biopharma, Prestige Biopharma, ONO PHARMACEUTICAL CO., LTD., Innovent Biologics, QLSF Biotherapeutics Inc., Servier, Zai Lab, EQRx, Bright Peak Therapeutics, Compass Therapeutics, Inc., Y-Biologics, Shattuck Labs, Beijing Biocytogen, Transcenta Holding, KLUS Pharma Inc., Synermore Biologics, F-Star Therapeutics Inc., Alphamab Oncology, Betta Pharmaceuticals Co., Ltd., Bolt Biotherapeutics, Medicenna Therapeutics, Celldex Therapeutics Inc., TCR² Therapeutics, Transcenta Holding, Merus, SystImmune Inc., TG Therapeutics, Elpiscience, Numab, Janux Therapeutics, Adagene, Molecular Templates, Inc., ImmuneOncia, and others
- Key PD-1 and PD-L1 Inhibitors Pipeline Therapies: Envafolimab, Keytruda, FAZ053, TECENTRIQ, Durvalumab, SG 12473, LP 002, HBM 9027, CA 170, Tislelizumab, Geptanolimab, and others.
Dive deep for rich insights into PD-1 inhibitors in development; visit @PD-L1 Inhibitor Drugs
Table of Contents
1. | PD-1 and PD-L1 Inhibitors Pipeline Report Introduction |
2. | PD-1 and PD-L1 Inhibitors Pipeline Report Executive Summary |
3. | PD-1 and PD-L1 Inhibitors Pipeline: Overview |
4. | Analytical Perspective In-depth Commercial Assessment |
5. | PD-1 and PD-L1 Inhibitors Clinical Trial Therapeutics |
6. | PD-1 and PD-L1 Inhibitors Pipeline: Late Stage Products (Pre-registration) |
7. | PD-1 and PD-L1 Inhibitors Pipeline: Late Stage Products (Phase III) |
8. | PD-1 and PD-L1 Inhibitors Pipeline: Mid Stage Products (Phase II) |
9. | PD-1 and PD-L1 Inhibitors Pipeline: Early Stage Products (Phase I) |
10. | PD-1 and PD-L1 Inhibitors Pipeline Therapeutic Assessment |
11. | Inactive Products in the PD-1 and PD-L1 Inhibitors Pipeline |
12. | Company-University Collaborations (Licensing/Partnering) Analysis |
13. | Key Companies |
14. | Key Products in the PD-1 and PD-L1 Inhibitors Pipeline |
15. | Unmet Needs |
16. | Market Drivers and Barriers |
17. | Future Perspectives and Conclusion |
18. | Analyst Views |
19. | Appendix |
For further information on the PD-1 and PD-L1 inhibitors pipeline therapeutics, reach out @PD-1 and PD-L1 Inhibitors Market
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