DJ Abivax announces presentation of four abstracts for obefazimod in ulcerative colitis and preclinical colon cancer model at Digestive Disease Week 2024
ABIVAX
Abivax announces presentation of four abstracts for obefazimod in ulcerative colitis and preclinical colon cancer model
at Digestive Disease Week 2024
08-May-2024 / 08:30 CET/CEST
Dissemination of a French Regulatory News, transmitted by EQS Group.
The issuer is solely responsible for the content of this announcement.
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Abivax announces presentation of four abstracts for obefazimod in ulcerative colitis and preclinical colon cancer model
at Digestive Disease Week 2024
PARIS, France, May 8, 2024, 8:30 a.m. CEST - Abivax SA (Euronext Paris & Nasdaq: ABVX) ("Abivax" or the "Company"), a
clinical-stage biotechnology company focused on developing therapeutics that harness the body's natural regulatory
mechanisms to stabilize the immune response in patients with chronic inflammatory diseases, today announced that four
scientific abstracts on its lead drug candidate, obefazimod, for the treatment of moderately to severely active
ulcerative colitis (UC) and in a preclinical model on colon cancer, will be presented at Digestive Disease Week (DDW)
as part of scientific exchange, taking place May 18-21, 2024, in Washington D.C., U.S.
"With four abstracts accepted for presentation at DDW 2024, we look forward to our continued exchange with the IBD
community around the emerging clinical profile of obefazimod," said Sheldon Sloan, M.D., M. Bioethics, Chief Medical
Officer of Abivax. "We are excited to share new preclinical data showing obefazimod's impact in reducing the number of
tumors in the azoxymethane (AOM)/dextran sodium sulfate (DSS) mouse model of colitis-associated cancer-data in support
of obefazimod's novel mechanism of action."
For more information, visit the Abivax booth at the DDW exhibitor hall (booth #529) or see congress details on the DDW
website.
Obefazimod data to be presented:
Presentation Session Date and
Presentation Title Session Presenter / Session Hall Time (EDT)
Number
Oral Presentation
Prof. Bruce E. Sands, M.D.,
M.S.
Efficacy and safety of obefazimod May 21,
in UC patients at weeks 48 and 96 2024
of an open-label maintenance IBD Controlled Trials
study among clinical responders II Dr. Burrill B. Crohn Professor 8:00-9:30
at week 8 of the Phase 2b of Medicine and Chief, Dr. a.m.
induction trial Henry D. Janowitz Division of
Gastroenterology, Icahn School
of Medicine at Mount Sinai, NY
Poster Presentations
Obefazimod and its active Didier Scherrer, Ph.D.
metabolites ABX-464-N-Glu act by Cell and Molecular May 18,
stabilizing protein-protein Biology of 2024
interaction among key RNA Gastrointestinal
biogenesis partners, CBC and ARS2 Disorders Chief Scientific Officer, 12:30-1:30
Abivax p.m.
GI Cancer Research Didier Scherrer, Ph.D. May 18,
Obefazimod reduces total number Models: Organoids, 2024
of tumors and high-grade adenomas Engineered Cell and
in a murine colitis associated Tissue Platforms, and 12:30-1:30
colorectal cancer model Animal Models Chief Scientific Officer, p.m.
Abivax
Prof. Bruce E. Sands, M.D.,
M.S.
Efficacy of once-daily, orally May 19,
administered obefazimod in IBD: Controlled 2024
patients with moderately to Clinical Trials in
severely active UC at weeks 8, Humans Dr. Burrill B. Crohn Professor 12:30-1:30
48, and 96 broken down by of Medicine and Chief, Dr. p.m.
induction treatment dose Henry D. Janowitz Division of
Gastroenterology, Icahn School
of Medicine at Mount Sinai, NY
Abivax has also sponsored a Product Theater presentation titled, "An Investigational New MOA that Can Stabilize the Inflammatory Response in Ulcerative Colitis," taking place on May 20, 2024, at 2:30-3:15 p.m. EDT in room "DDW Theater 1," featuring Prof. Parambir S. Dulai, M.D., Associate Professor of Medicine in the Division of Gastroenterology and Hepatology at Northwestern University, Evanston, Illinois, U.S.
About Obefazimod
Obefazimod, Abivax's lead investigational drug candidate, is an orally administered small molecule that was demonstrated to potentially enhance the expression of a single microRNA, miR-124. Phase 2 clinical trials in patients with UC have generated positive data, resulting in the initiation of a pivotal global Phase 3 clinical trial program (ABTECT Program), with first patients enrolled in the United States in October 2022. Initiation of a Phase 2b clinical trial in Crohn's disease is expected in Q3 2024, and exploration of potential combination therapy opportunities in UC is ongoing. About Abivax
Abivax is a clinical-stage biotechnology company focused on developing therapeutics that harness the body's natural regulatory mechanisms to stabilize the immune response in patients with chronic inflammatory diseases. Based in France and the United States, Abivax's lead drug candidate, obefazimod (ABX464), is in Phase 3 clinical trials for the treatment of moderately to severely active ulcerative colitis. More information on the Company is available at www.abivax.com. Follow us on LinkedIn and on X, formerly Twitter, @Abivax. Contact:
Abivax Investor Relations
Patrick Malloy
patrick.malloy@abivax.com
+1 847 987 4878
Abivax Communications
communications@abivax.com
FORWARD-LOOKING STATEMENTS
This press release contains forward-looking statements, forecasts and estimates, including those relating to the Company's business and financial objectives. Words such as "design," "expect," "forward," "future," "potential," "plan," "project" and variations of such words and similar expressions are intended to identify forward-looking statements. Although Abivax's management believes that the expectations reflected in such forward-looking statements are reasonable, investors are cautioned that forward-looking information and statements are subject to various risks, contingencies and uncertainties, many of which are difficult to predict and generally beyond the control of Abivax, that could cause actual results and developments to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. A description of these risks, contingencies and uncertainties can be found in the documents filed by the Company with the French Autorité des Marchés Financiers pursuant to its legal obligations including its universal registration document (Document d'Enregistrement Universel) and in our Annual Report on Form 20-F filed with the U.S. Securities and Exchange Commission on April 5, 2024 under the caption "Risk Factors." These risks, contingencies and uncertainties include, among other things, the uncertainties inherent in research and development, future clinical data and analysis, decisions by regulatory authorities, such as the FDA or the EMA, regarding whether and when to approve any drug candidate, as well as their decisions regarding labelling and other matters that could affect the availability or commercial potential of such product candidates. Special consideration should be given to the potential hurdles of clinical and pharmaceutical development including further assessment by the company and regulatory agencies and IRBs/ethics committees following the assessment of preclinical, pharmacokinetic, carcinogenicity, toxicity, CMC and clinical data. Furthermore, these forward-looking statements, forecasts and estimates are only as of the date of this press release. Readers are cautioned not to place undue reliance on these forward-looking statements. Abivax disclaims any obligation to update these forward-looking statements, forecasts or estimates to reflect any subsequent changes that the Company becomes aware of, except as required by law. Information about pharmaceutical products (including products currently in development) that is included in this press release is not intended to constitute an advertisement. This press release is for information purposes only, and the information contained herein does not constitute either an offer to sell, or the solicitation of an offer to purchase or subscribe securities of the Company in any jurisdiction. Similarly, it does not give and should not be treated as giving investment advice. It has no connection with the investment objectives, financial situation or specific needs of any recipient. It should not be regarded by recipients as a substitute for exercise of their own judgment. All opinions expressed herein are subject to change without notice. The distribution of this document may be restricted by law in certain jurisdictions. Persons into whose possession this document comes are required to inform themselves about and to observe any such restrictions.
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Regulatory filing PDF file File: 240508_Abivax_PR_DDW Curtain Raiser
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Language: English
Company: ABIVAX
5, Rue de La Baume
75008 Paris
France
E-mail: info@abivax.de
Internet: www.abivax.de
ISIN: FR0012333284
Euronext Ticker: ABVX
AMF Category: Inside information / Other releases
EQS News ID: 1896807
End of Announcement EQS News Service
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1896807 08-May-2024 CET/CEST
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May 08, 2024 02:30 ET (06:30 GMT)
