Anzeige
Mehr »
Login
Sonntag, 22.12.2024 Börsentäglich über 12.000 News von 679 internationalen Medien
Die erste börsennotierte Gesellschaft, die auf das gemeinsame Wachstum von Solana, XRP und Dogecoin setzt!
Anzeige

Indizes

Kurs

%
News
24 h / 7 T
Aufrufe
7 Tage

Aktien

Kurs

%
News
24 h / 7 T
Aufrufe
7 Tage

Xetra-Orderbuch

Fonds

Kurs

%

Devisen

Kurs

%

Rohstoffe

Kurs

%

Themen

Kurs

%

Erweiterte Suche

WKN: A0B7QK | ISIN: GB0034330679 | Ticker-Symbol: DWV
Frankfurt
20.12.24
21:50 Uhr
0,108 Euro
-0,005
-4,42 %
Branche
Dienstleistungen
Aktienmarkt
Sonstige
1-Jahres-Chart
ANGLE PLC Chart 1 Jahr
5-Tage-Chart
ANGLE PLC 5-Tage-Chart
RealtimeGeldBriefZeit
0,1740,19021.12.
ACCESSWIRE
225 Leser
Artikel bewerten:
(1)

Angle PLC Announces Exclusive agreement for DNA NGS panel

Finanznachrichten News

ANGLE ANNOUNCES NEXT GENERATION SEQUENCING ASSAY AGREEMENT WITH NUPROBE

Option for exclusive licence to highly sensitive NGS assay for use with CTCs and dual analysis of CTCs with ctDNA

Combining the Parsortix system with comprehensive DNA molecular analysis opens up a broad range of pharma services opportunities

GUILDFORD, SURREY / ACCESSWIRE / September 23, 2024 / ANGLE plc (AIM:AGL)(OTCQX:ANPCY), a world-leading liquid biopsy company with innovative circulating tumour cell (CTC) solutions for use in research, drug development and clinical oncology, is delighted to announce that it has signed an agreement with the cutting-edge genomics and molecular diagnostics company, NuProbe USA, Inc. ("NuProbe"), to use its proprietary pan-cancer next generation sequencing (NGS) panel ("the NGS panel").

Under the terms of the agreement, NuProbe has granted the Company an option for an exclusive global license to the NGS panel outside of China for the analysis of CTCs and the dual analysis of CTCs and ctDNA. In this first stage of the collaboration, NuProbe will transfer manufacture of the NGS panel to a larger-scale manufacturing site and ANGLE will undertake internal validation of the initial batches.

The NGS panel, which has been validated on the Illumina sequencer, enables highly sensitive and specific detection of over 6,500 DNA mutations in 61 clinically relevant genes and been found to be the highest performing multi-gene assay of those evaluated by ANGLE. These genes include those with matched targeted therapies currently selected using assays which use tumour tissue or circulating tumour DNA (ctDNA) and aligns with many key drug targets under development by large pharma.

This agreement will help accelerate the Company's ability to commercialise its first pan-cancer molecular sequencing assay either for CTC-DNA analysis alone or dual analysis of CTCs and ctDNA from a single blood sample. The NGS panel enables highly sensitive and specific high throughput gene analysis and has immediate applicability to ANGLE's pharma services customers and translational researchers using the Parsortix® system. In the longer-term, repeatable, minimally invasive, molecular profiling using liquid biopsy analytes has the potential to be a key step for clinicians tracking tumour evolution, treatment response, early identification of drug resistance and disease progression.

The Company has already successfully completed a pilot study with the NGS panel, with results published at the EACR Annual Meeting in June 2024 (see: https://angleplc.com/resources/posters/). In this study CTC-DNA (from CTCs harvested using the Parsortix system) and ctDNA were evaluated in blood samples from breast, lung and ovarian cancer patients. In all three cancer types, more mutations were identified exclusively in CTCs, as compared to ctDNA alone, highlighting the potential value of profiling CTCs in addition to ctDNA.

NuProbe Chief Executive Officer, Yingshuang Chai, commented:

"We are excited to enter into an agreement with ANGLE plc, a world leader in the harvest of CTCs from blood for analysis. NuProbe's NGS panel is a low-cost, ultra-sensitive pan-cancer NGS panel that can accurately detect mutations and has demonstrated robust performance in both CTC and ctDNA sample types. By combining CTC and ctDNA detection, this collaboration will help drive the development of personalised treatment options for cancer patients. We look forward to the development of a strong partnership with ANGLE in the future."

ANGLE Chief Executive Officer, Andrew Newland, commented:

"We are delighted to have signed an agreement with NuProbe which grants the Company an exclusive worldwide licence option (outside of China) to the NGS panel for the analysis of CTCs and dual analysis of CTCs and ctDNA. The Company's marker-independent Parsortix system has been exemplified in 24 cancer types representing 90% of all solid tumour cases. As such we are strongly positioned to leverage a pan-cancer gene panel across 61 oncogenes and thousands of mutations. The Company believes that this agreement will enable us to combine the leading CTC harvesting solution with an optimised DNA sequencing panel for analysis of CTCs and dual analysis of CTCs and ctDNA."

ANGLE Chief Scientific Officer, Karen Miller commented:

"We are pleased to sign an agreement with NuProbe which will support our ongoing development of highly sensitive and specific molecular assays using CTCs harvested using the Parsortix system together with ctDNA from a single blood sample. Dual analysis of CTCs and ctDNA can provide additional and complementary information which will provide pharma services customers with unparalleled and repeatable insights into a range of cancers, and in the longer-term provide clinicians with the potential for continual optimisation of personalised cancer treatment plans."

For further information:

ANGLE plc

+44 (0) 1483 343434

Andrew Newland, Chief Executive

Ian Griffiths, Finance Director

Berenberg (NOMAD and Broker)

Toby Flaux, Ciaran Walsh, Milo Bonser

+44 (0) 20 3207 7800

FTI Consulting

Simon Conway, Ciara Martin

Matthew Ventimiglia (US)

+44 (0) 203 727 1000

+1 (212) 850 5624

The information contained within this announcement is deemed by the Company to constitute inside information as stipulated under the EU Market Abuse Regulation (596/2014).Upon the publication of this announcement via a regulatory information service, this information is considered to be in the public domain.

For Research Use Only. Not for use in diagnostic procedures.

For Frequently Used Terms, please see the Company's website on https://angleplc.com/investor-relations/glossary/

Notes for editors

About ANGLE plc

ANGLE is a world-leading liquid biopsy company with innovative circulating tumour cell (CTC) solutions for use in research, drug development and clinical oncology using a simple blood sample. ANGLE's FDA cleared and patent protected circulating tumour cell (CTC) harvesting technology known as the Parsortix® PC1 System enables complete downstream analysis of the sample including whole cell imaging and proteomic analysis and full genomic and transcriptomic molecular analysis.

ANGLE's commercial businesses are focusing on diagnostic products and clinical services. Diagnostic products include the Parsortix® system and associated consumables. The clinical services business is offered through ANGLE's GCP-compliant laboratories in the UK. Services include custom made assay development and clinical trial testing for pharma.

Over 90 peer-reviewed publications have demonstrated the performance of the Parsortix system. For more information, visit www.angleplc.com

AboutNuProbe

NuProbe is a cutting-edge genomics and molecular diagnostics company with revolutionary molecular diagnostic technologies to improve the sensitivity of sequencing mutations and copy number variations by over 10-fold. NuProbe has sites in Houston, USA, Shanghai, China and Suzhou, China. NuProbe's vision is to offer affordable, timely, and accurate disease state information to enable precision medicine and improve patient outcomes.

This information is provided by RNS, the news service of the London Stock Exchange. RNS is approved by the Financial Conduct Authority to act as a Primary Information Provider in the United Kingdom. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@lseg.com or visit www.rns.com.

SOURCE: ANGLE plc



View the original press release on accesswire.com

© 2024 ACCESSWIRE
6 Richtige für 2025
Das Börsenjahr 2025 klopft schon an die Tür – und wie immer geht es um die Frage: Welche Aktien werden die großen Gewinner sein? Die Auswahl an Möglichkeiten ist riesig, doch nur ein paar echte Volltreffer stechen heraus.

Ob stabiler Dividenden-Lieferant, Tech-Pionier oder spekulative Wette im Krypto-Bereich – wir haben die Märkte für Sie ausgiebig durchforstet und präsentieren Ihnen 6 Unternehmen, die große Chancen auf außergewöhnliche Kurssteigerungen besitzen. Hier sind, speziell für Sie, Ihre „6 Richtigen“ für 2025.

Fordern Sie jetzt unseren neuen kostenlosen Spezialreport an und erfahren Sie, welche Unternehmen das Potenzial besitzen, im kommenden Jahr richtig durchzustarten!
Werbehinweise: Die Billigung des Basisprospekts durch die BaFin ist nicht als ihre Befürwortung der angebotenen Wertpapiere zu verstehen. Wir empfehlen Interessenten und potenziellen Anlegern den Basisprospekt und die Endgültigen Bedingungen zu lesen, bevor sie eine Anlageentscheidung treffen, um sich möglichst umfassend zu informieren, insbesondere über die potenziellen Risiken und Chancen des Wertpapiers. Sie sind im Begriff, ein Produkt zu erwerben, das nicht einfach ist und schwer zu verstehen sein kann.